2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenylate Cyclase

Adenylate Cyclase

Adenylyl cyclase

Adenylate Cyclase

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Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Adenylyl cyclases integrate positive and negative signals that act through G protein-coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of cAMP within the cell. Humans express nine isoforms of membranous ACs and a soluble AC.

Based on regulatory properties, transmembrane ACs are classified into four groups: Group I: Ca2+/calmodulin-stimulated AC1, AC3, AC8; Group II: Gβγ-stimulated and Ca2+-insensitive AC2, AC4, AC7; Group III: Gαi/Ca2+/PKA-inhibited AC5, AC6; Group IV: forskolin/Ca2+/Gβγ-insensitive AC9. The soluble AC, unlike the transmembrane ACs, is insensitive to hormones, G proteins and forskolin, a diterpene extracted from the root of the plant Coleus forskohlii that directly activates all isoforms of transmembrane ACs except AC9.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0004A
    Lysipressin acetate
    		Activator 99.43%
    Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.
    Lysipressin acetate
  • HY-P99509
    Zelminemab
    		Inhibitor
    Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor.
    Zelminemab
  • HY-101862
    CB-7921220
    		Inhibitor ≥98.0%
    CB-7921220 is an adenylate cyclase inhibitor.
    CB-7921220
  • HY-116530
    9-Cyclopentyladenine monomethanesulfonate
    		Inhibitor 99.16%
    9-Cyclopentyladenine monomethylsulfonate (9-CP-Ade mesylate) is a stable non-competitive adenylate cyclase inhibitor with cell permeable properties.
    9-Cyclopentyladenine monomethanesulfonate
  • HY-146356
    Adenylyl cyclase type 2 agonist-1
    		Agonist 99.30%
    Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC50 of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases.
    Adenylyl cyclase type 2 agonist-1
  • HY-N10772
    Albanin A
    		Inhibitor
    Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.
    Albanin A
  • HY-103430
    SKF-83566 hydrobromide
    		Antagonist
    SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM). SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta. SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation.
    SKF-83566 hydrobromide
  • HY-P2090A
    Angiopeptin TFA
    		Inhibitor 99.71%
    Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.
    Angiopeptin TFA
  • HY-14425
    NB001
    		Inhibitor 98.21%
    NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity.
    NB001
  • HY-115748A
    Mant-GTPγS triammonium
    		Inhibitor
    Mant-GTPγS triammonium, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS triammonium is a potent YdeH inhibitor.
    Mant-GTPγS triammonium
  • HY-P3689
    [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
    		Activator 99.89%
    [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and adenylate cyclase. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system.
    [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
  • HY-145830
    AC1-IN-1
    		Inhibitor 99.81%
    AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.
    AC1-IN-1
  • HY-P1495
    Small Cardioactive Peptide B (SCPB)
    		Activator 98.10%
    Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
    Small Cardioactive Peptide B (SCPB)
  • HY-100767
    Guanylyl Imidodiphosphate trisodium
    		Activator
    Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies.
    Guanylyl Imidodiphosphate trisodium
  • HY-108565
    BMY 45778
    		Activator
    BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor.
    BMY 45778
  • HY-P3647
    [DPro10] Dynorphin A (1-11), porcine
    		Inhibitor
    [DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property.
    [DPro10] Dynorphin A (1-11), porcine
  • HY-115748
    Mant-GTPγS
    		Inhibitor
    Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor.
    Mant-GTPγS
  • HY-P2090
    Angiopeptin
    		Inhibitor
    Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.
    Angiopeptin
  • HY-P3117
    PACAP (6-27) (human, ovine, rat)
    		Antagonist
    PACAP (6-27) (human, ovine, rat) is a PACAP receptor antagonist that blocks the canine adrenal catecholamine response to exogenous vasoactive intestinal peptide (VIP). PACAP (6-27) (human, ovine, rat) has the potential to study cardiovascular and neurological diseases.
    PACAP (6-27) (human, ovine, rat)
  • HY-P3647A
    [DPro10] Dynorphin A (1-11), porcine hydrochloride
    		Inhibitor
    [DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property.
    [DPro10] Dynorphin A (1-11), porcine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity